Amanda S. (33), Phoenix, AZ
60 capsules– two months supply
60 capsules– two months supply
Amanda S. (33), Phoenix, AZ
Hanna R. (24), New London, CT
Electrical engineering student, avid fitness dude
Former pro athlete, US Army Jumpmaster, current timber wrestler for new log cabin
For those that want maximum strength formula, Signalom™ means adaptive, pre-protection of organs and tissue, maximum energy, more complete recovery and of course adaptive protection against immune challenges.
With regular strength formula, you get whole-body immune activation before immune challenges even occur, additional energy, adaptive protection against future immune challenges, and the peace of mind in knowing that that you have significantly fortified and optimized your homeostasis.Stress, lack of sleep, overwork, and exhaustion can all reduce available oxygen to cells which reduces energy and suppresses immunity. Athletes build strength with intensive exercising, but this depletes available oxygen in cells and tissues that, until recovery, suppresses immunity. When pathogens invade, oxygen levels in cells are depleted as our cells battle with the invaders for oxygen and nutrients. Some pathogens actually induce low oxygen conditions specifically to delay and suppress our immune response. You might be surprised to learn that most immune challenges quickly lead to low oxygen tensions in cells, tissues and organs. As we age, all of these oxygen & energy related challenges become more difficult as our ability to respond with speed and vigor is reduced. Your body has a built-in fix, all triggered by one signal that initiates more than 100 actions designed to quickly restore oxygen to cells, provides access to energy reserves that we all have, additionally creates energy that doesn't require oxygen, and adds protection for all of our organs and tissues. Triggering these beneficial actions fortifies our immunity and vigorously supports homeostasis no matter your age. The natural trigger for all of these actions happens to be the most energetically powerful substrate in the Krebs cycle called succinate which signals both local cells and the brain to action. Succinate is the only metabolite in our body known to perform this absolutely vital function. Signalom™ formulas are based upon natural succinate metabolites signalling local tissues and the brain to action within 20 minutes. Once activated by succinate, immune cells will engage more quickly and with more energy. Once activated by succinate, the hypothalamus in the brain exerts necessary whole-body coordination to anticipate and respond to challenges. Pre-activated cells are much less susceptible to pathogen invasion. Could it possibly get any better? Yes! Research has shown that in as little as 7-14 days, daily succinate supplements can help restore sensitivity in the hypothalamus lost due to aging. This is HUGE, especially for seniors, as pre-activated immune systems can engage more quickly when pathogen loads are low. The secret to using succinate as a supplement is quite simply to only briefly trigger the brain and tissues to action, and then get out of the way so fortified homeostasis can direct our immune systems and stress responses in concert with one another as necessary. Especially important for the challenges we face today, Signalom™ is the biohack of the century for both young and old. Choose the product or combination that works best for you. Many people find that Signalom™ PRO-SPORT works best on especially stressful days, for heavy workout, or competition when maximum energy and recovery are most important, and Signalom™ ACTIVE works best on more normal days. Either way, you get all 100 beneficial actions including pre-activated, whole-body immunity boost beginning within 20 minutes. Be healthy, be strong-- no matter the challenge!
Metabolites are either the compounds used in metabolism, or can also be the product of metabolism. Primary metabolites are compounds that are synthesized in cells and are necessary for the survival and growth of the cell. Signalom formulations contain primary metabolites and, in some cases, include specific vitamins by design to perform specific functions.
Vitamins and minerals are organic compounds that cannot be synthesized in the body and are used as functional parts of enzymes in metabolism.
Biological sciences tell us that there are more than 40,000 identified metabolites in humans. Of these, only succinate metabolites are directly involved in ATP (energy) production and cellular signaling (electron transport chain). Signalom products are all based upon succinic acid and it’s relevant salts (succinates). Our Signalom™ formulations are all uniquely effective and patent protected.
Signalom™ products introduce naturally occurring metabolites that initiate and inhibit specific cascade reactions in mitochondria, cells and bio-systems. These specific cascade reactions support performance, recovery, signaling, regulatory, cardio, cognitive and CNS functions. Signalom products also include actual geroprotectors and antioxidant groups. The quantities involved are designed to induce a cooperative, cascade effect, as opposed to a stand-alone function. In this way, natural processes are supported or enhanced, not replaced.
The metabolite-vitamin formulas in Signalom™ Pro-Sport, Signalom™ Active and coming soon Signalom™ Sentinel, have been separated by design so as not to metabolically compete with each other.
Generally speaking, most anyone can take 1-3 capsules per day—the more your body weight, the slightly more signal you may need. Our testing confirms that there is no toxicity even at tenfold increase, so no worries in that regard.
As a rule of thumb, if your body weight is less than 180 lbs. (~80 kg), normally one capsule is enough for a good signal. If your body weight is more, you might need another capsule to initiate the desired result. Many people weighing up to 220 lbs. and more feel the beneficial effects with just one capsule. See what works best for you.
♦ When pathogens invade, available oxygen is quickly used by resident and circulating immune cells to create energy to powers our many defenses
♦ As oxygen supplies quickly decrease, a signal is sent to neighboring cells and to the brain to activate the low-oxygen protocol wired into each cell’s DNA
♦ The low-oxygen protocol involves more than 100 genetic actions including multi-level immune support to infected tissue areas, and additional energy to immune cells
♦ Within 20 minutes, practically all cells become activated, and activated cells are much more resistant to pathogen invasion
♦ The signaling molecule is succinate
Signalom™ products contain naturally occurring metabolites.
More than 450 volunteers including Olympic athletes, professional athletes, high-level amateur athletes and non-athlete adult volunteers were tested utilizing double-blind, placebo controlled human trials (considered the ‘gold standard’ of clinical trials). This means that neither the participant nor the attending researcher knew who was given a placebo and who was given the supplement. Results were then calculated using standardized clinical methodology to determine statistical significance.
Throughout our entire testing period (3+ years) and among all volunteers, no adverse side effects were noted.
Yes! In fact, both products are immune boosting.
There are two groups of benefits in both of our succinate formulas:
Both groups of benefits are absolutely necessary to effectively fortify your immune systems. Signalom™ Pro-Sport accentuates primarily the first group of energetics benefits, while Signalom™ Active accentuates more the second group of benefits by adding in antioxidant activators.
Both products incorporate aspects of both groups of benefits.
Some people get confused by the name—and understandably so! When we first researched, formulated and began marketing these products, we knew that there were two groups of benefits activated by our formulas. We decided to market the supplements for their energetics benefits as sports and activity supplements—and we named the products accordingly. Later, we came to understand that many people were most interesting in the immunity boosting benefits, but the sports and activity names stuck!
Regardless of the name, the two groups of benefits combine to initiate a cascade of more than 100 beneficial actions that naturally provide you with a well-coordinated, responsive immunity boost within 20 minutes.
If you need a strong boost in the energetics and recovery, take Signalom™ Pro-Sport. If you’re not risking overly intensive activity, you might prefer a bit more of the antioxidant action, take Signalom™ Active. Often, people mix the two taking Signalom™ Pro-Sport on heavy work or intensive exercise days, and taking Signalom™ Active on all other days.
A biohack refers to actions that people take to make their bodies and brains function better. Signalom™ formulations are natural “biohacks” because you can induce all of these beneficial actions on your own with the proper technique and exercise regime (you can learn much more by looking up “hypoxia preconditioning” in your search engine)! The issue is that it takes quite a bit of energy and understanding to trigger these adaptive responses on your own and how do you know if you’re doing enough, or too much, right?
We can help.
For those who wish to learn more, provided here is the link to an excellent and relevant academic manuscript entitled, “Effect of exercise on the immune system: response, adaptation and cell signaling.”
Summary: Over the last century, people have become less active, adopting more sedentary habits. This scenario has increased the incidence of chronic diseases such as cardiovascular diseases, type 2 diabetes and metabolic syndrome. The practice of physical activities can influence healthiness by altering the metabolic state and also the immune system. The current state of knowledge suggests that the alterations in the immune system are dependent on parameters inherent to exercise and that in order to have all these alterations occurring, some cell signaling cascades are activated, giving rise to a complex process of phosphorylation/dephosphorylation that culminates in the activation of transcription factors, translation of mRNA’s, protein synthesis and cell proliferation.
Generally speaking, exercise of moderate intensity promotes protection against infections caused by intracellular microorganisms, since it guides the immune response to a predominance of Th1 cells. Conversely, high-intensity activities cause increases the concentrations of anti-inflammatory cytokines (Th2 pattern), presumably to decrease damage in muscular tissue resulting from inflammation.
The Signalom™ biohack is that exact, beneficial activation, and the secret is a Goldilocks signal—too short or weak a signal to the hypothalamus in your brain and nothing happens, too long-term or strong a signal and you can suppress some important benefits. You only need enough to make a proper signal, not to perform a function. Use the science to your advantage! When the signal strength is adequate then you get all of the short and long-term benefits of a well-coordinated and responsive immunity boost. Exercise and enjoy life to its fullest—its great for your health and immunity!
♦ In general, there are two parts to the human immune system: innate (or broad-spectrum) and adaptive.
♦ Innate immune cells are found both in circulating blood and in tissues and are the first to engage pathogens, normally within several hours or up to several days after infection when the pathogen load is low
♦ Innate immune cells lack the ability to specifically identify pathogens, they just know that it is not one of ours and must be destroyed; dead pathogens are ultimately transported to the thymus gland where innate and adaptive immunity meet.
♦ After obtaining the specific pathogen information from innate immune cells in the thymus gland, adaptive immune cells are subjected to rigorous training in order to quickly learn how to recognize and kill the pathogen and not confuse it with our own cells; upon successful training, new adaptive immune cells are mass produced, called ‘clonal expansion,’ normally taking around 4-7 days after infection.
♦ Immune cells use inflammation to kill pathogens
♦ Inflammation requires energy and most cellular energy is made using oxygen
♦ Many types of immune challenges can quickly deplete cellular oxygen
♦ In almost all cases, the first and most important order of business is to restore cellular oxygen and energy
Activate Biophysics Corp. is a privately held technology company incorporated in Vancouver, British Columbia. Since 2015, the Company’s founders commissioned testing and human trials for a unique, non-toxic and highly effective line of dietary supplements. The Company was formed to bring these products to market in North America, the EU and Asia. The Company has applied for patent protection for all of its unique formulations.
The mission of the Company is to develop, manufacture and market non-toxic, highly effective dietary supplements throughout the world. Our vision is to become the world’s primary supplier of biophysics-based dietary supplements.
In accordance with our mission statement, the Company is currently developing a pipeline of additional non-toxic and highly effective products and supplements to help provide our customers (and ourselves) with optimum health.