Signalom PRO-SPORT

Within 20 Minutes Promotes:

[for 2-3 hrs.] First Window of Benefits– highest energetics availability including:

  • Horsepower energy: addition of anaerobic energy generation is up to 10 times faster than normal aerobic energy generation.  When combined using succinate, your mixed metabolic state provides the most powerful energetics.
  • Ketone energy reserve access in your liver– researchers estimate your reserve to be around 2,000 calories.
  • Neuro-muscular accuracy: Your brain uses more energy than any other organ in the body and is extremely sensitive to low oxygen.  Low oxygen equals poor performance.  Succinate metabolites account for greater blood flow to the brain and more efficient use of oxygen in every cell which is especially important when you are fatigued helping you make better, faster, more accurate athletic decisions, and helping you to prevent injury.
  • Gluconeogenesis: Your whole-body activated Cori cycle quickly converts lactate (and some amino acids) back to glucose energy for use in your exercising muscles or your brain.

[for up to 48 hrs.] Second Window of Benefits–  multi-function regulatory support:

  • HIF (hypoxia inducible factor) and NRF2 (nuclear factor erythroid 2-related factor), are arguably two of the most powerful, natural genetic triggers each activating more than 100 genetic actions.  Succinate activates HIF with a brief signal, and HIF activates NRF2.  Within 20 minutes, all immune cells are activated and all organs and tissues acquire additional support.  Activated cells  vigorously support homeostasis against multiple pathogen and other immune challenges.  Coronaviruses, like all retroviruses, find it very difficult to survive and multiply if antioxidant systems in cells are activated.
  • Rapid recovery: The Cori cycle continues to work efficiently once your muscle activity has ceased as your liver continues to convert lactate and restore your oxygen levels and ketones (lactic acid remains elevated in your post-exercise recovery). The more exercise-trained your skeletal muscles, the greater your ability to utilize ketone bodies for fuel.  At night, depleted energy reserves are restored.
  • Microbiota and intestinal mucosa: soon after ingestion, succinate promotes the formation of regulators in your gut that support activity for your various organs and systems including–
  • Liver: an increase in your liver function due to activation of the Cori cycle provides additional support for your increased muscle and brain activities.
  • Heart: The activation of heart buffering mechanisms during heavy exercise often leads athletes to report a lower training heart rate and without loss of power.
  • Central Nervous System: Succinate metabolites utilize neurotransmitters in your gut-brain axis to activate SCNR1 receptors and control calcium ion channels in your neurons. Calcium ion signaling in your brain is known to bring about a positive mood in many athletes.
  • Brain: Once activated by succinate metabolites, your hypothalamus continues to exert positive influence on all of your organs and bio-systems. While sensitivity to succinate in the brain can diminish with age, studies have shown that even a short course of supplemental succinate metabolites used as per instructions can improve the sensitivity of body’s primary stress response controller, the hypothalamus.  Rapid engagement of the hypothalamus promotes robust homeostasis.

NOTE: Signalom™ products interact with your gut microbiota to quickly and effectively metabolize in your  intestinal mucosa stimulating the gut-brain axis. Most people notice various positive effects soon afterwards. If you feel that your effects with this product are muted, consider adding in a good probiotic.

Signalom Active

Within 20 Minutes Promotes:

[for 2-3 hrs.] First window of benefits– high energetics availability including:

  • Horsepower energy: the addition of anaerobic energy generation is up to 10 times faster than your normal aerobic energy generation.  When combined using succinate, your mixed metabolic state provides powerful energetics for the many different cellular and system functions.
  • Ketone energy reserve access in your liver– researchers estimate your reserve to be around 2,000 calories.
  • Neuro-muscular accuracy: Your brain uses more energy than any other organ in the body and is extremely sensitive to low oxygen.  Succinate metabolites account for greater blood flow to the brain and more efficient use of oxygen in every cell which is especially important when you are fatigued helping you make better, faster, more accurate athletic decisions, and helping you to prevent injury.
  • Gluconeogenesis: Your whole-body activated Cori cycle quickly converts lactate (and some amino acids) back to glucose energy for use in your exercising muscles or in your brain.

[for up to 48 hrs.] Second window of benefits– multi-function regulatory support including:

  • HIF (hypoxia inducible factor) and NRF2 (nuclear factor erythroid 2-related factor), are arguably two of the most powerful, natural genetic triggers each activating more than 100 genetic actions.  Succinate activates HIF with a brief signal, and HIF activates NRF2.  Within 20 minutes, all immune cells are activated and all organs and tissues acquire additional support.  Activated cells  vigorously support homeostasis against multiple pathogen and other immune challenges.  Coronaviruses, like all retroviruses, find it very difficult to survive and multiply if antioxidant systems in cells are activated.
  • Rapid recovery: The Cori cycle continues to work efficiently once your muscle activity has ceased as your liver continues to convert lactate and to restore your oxygen levels and ketones (lactic acid remains elevated in your post-exercise recovery). At night, depleted energy reserves are restored.
  • Microbiota and intestinal mucosa: soon after ingestion, succinate promotes the formation of regulators in your gut that support activity for your various organs and systems including–
  • Liver: an increase in your liver function due to activation of the Cori cycle provides additional support for your increased muscle and brain activities.
  • Heart: The activation of heart buffering mechanisms during heavy exercise often leads athletes to report a lower training heart rate and without loss of power.
  • Central Nervous System: Succinate metabolites utilize neurotransmitters in your gut-brain axis to activate SCNR1 receptors and control calcium ion channels in your neurons. Calcium ion signaling in your brain is known to bring about a positive mood in many people.
  • Brain: Once activated by succinate metabolites, your hypothalamus continues to exert positive influence on all of your organs and bio-systems.  While sensitivity to succinate in the brain can diminish with age, studies have shown that even a short course of succinate metabolites used as per instructions can improve the sensitivity of body’s primary stress response controller, the hypothalamus.  Rapid engagement of the hypothalamus promotes robust homeostasis.
  • Anti-inflammatory action: Signalom™ Active includes additional metabolites and substrates that support your own anti-inflammatory mechanisms (i.e. does not replace your anti-inflammatory mechanisms, rather supports them).  NRF2 activation (see above) directly supports your body’s powerful anti-inflammatory mechanisms.
  • Antioxidant action: Signalom™ Active includes additional metabolites and substrates that support your own antioxidant mechanisms.  Coronaviruses, like all retroviruses, find it very difficult to survive and multiply if antioxidant systems in cells are activated.

NOTE: Signalom™ products quickly and effectively metabolize in your gut microbiota and intestinal mucosa. Most people notice various positive effects soon afterwards. If you feel that your effects with this product are muted, consider adding in a good probiotic.

How are Signalom™ products different than vitamins and other supplements?

Metabolites are either the compounds used in metabolism, or can also be the product of metabolism.  Primary metabolites are compounds that are synthesized in cells and are necessary for the survival and growth of the cell.  Signalom formulations contain primary metabolites and, in some cases, include specific vitamins by design to perform specific functions.

Vitamins and minerals are organic compounds that cannot be synthesized in the body and are used as functional parts of enzymes in metabolism.

Biological sciences tell us that there are more than 40,000 identified metabolites in humans. Of these, only succinate metabolites are directly involved in ATP (energy) production and cellular signaling (electron transport chain).  Signalom products are all based upon succinic acid and it’s relevant salts (succinates).  Our Signalom™ formulations are all uniquely effective and patent protected.

Signalom™ products introduce naturally occurring metabolites that initiate and inhibit specific cascade reactions in mitochondria, cells and bio-systems. These specific cascade reactions support performance, recovery, signaling, regulatory, cardio, cognitive and CNS functions.  Signalom products also include actual geroprotectors and antioxidant groups.  The quantities involved are designed to induce a cooperative, cascade effect, as opposed to a stand-alone function.  In this way, natural processes are supported or enhanced, not replaced.

The metabolite-vitamin formulas in Signalom™ Pro-Sport, Signalom™ Active and coming soon Signalom™ Sentinel, have been separated by design so as not to metabolically compete with each other.

How do I know the best dosage for me?

Generally speaking, most anyone can take 1-3 capsules per day—the more your body weight, the slightly more signal you may need.  Our testing confirms that there is no toxicity even at tenfold increase, so no worries in that regard.

As a rule of thumb, if your body weight is less than 180 lbs. (~80 kg), normally one capsule is enough for a good signal.  If your body weight is more, you might need another capsule to initiate the desired result.  Many people weighing up to 220 lbs. and more feel the beneficial effects with just one capsule.  See what works best for you.

How does succinate boost immunity?

♦  When pathogens invade, available oxygen is quickly used by resident and circulating immune cells to create energy to powers our many defenses

♦  As oxygen supplies quickly decrease, a signal is sent to neighboring cells and to the brain to activate the low-oxygen protocol wired into each cell’s DNA

♦  The low-oxygen protocol involves more than 100 genetic actions including multi-level immune support to infected tissue areas, and additional energy to immune cells

♦  Within 20 minutes, practically all cells become activated, and activated cells are much more resistant to pathogen invasion

♦  The signaling molecule is succinate

How were Signalom™ products tested?

Signalom™ products contain naturally occurring metabolites.

More than 450 volunteers including Olympic athletes, professional athletes, high-level amateur athletes and non-athlete adult volunteers were tested utilizing double-blind, placebo controlled human trials (considered the ‘gold standard’ of clinical trials). This means that neither the participant nor the attending researcher knew who was given a placebo and who was given the supplement. Results were then calculated using standardized clinical methodology to determine statistical significance.

Throughout our entire testing period (3+ years) and among all volunteers, no adverse side effects were noted.

Is Signalom™ Pro-Sport an immunity booster?

Yes! In fact, both products are immune boosting.

There are two groups of benefits in both of our succinate formulas:

  1. Primarily energetics, recovery, Cori cycle, oxygen efficiency
  2. Regulatory, organ and tissue protection

Both groups of benefits are absolutely necessary to effectively fortify your immune systems. Signalom™ Pro-Sport accentuates primarily the first group of energetics benefits, while Signalom™ Active accentuates more the second group of benefits by adding in antioxidant activators.

Both products incorporate aspects of both groups of benefits.

Some people get confused by the name—and understandably so!  When we first researched, formulated and began marketing these products, we knew that there were two groups of benefits activated by our formulas.  We decided to market the supplements for their energetics benefits as sports and activity supplements—and we named the products accordingly.  Later, we came to understand that many people were most interesting in the immunity boosting benefits, but the sports and activity names stuck!

Regardless of the name, the two groups of benefits combine to initiate a cascade of more than 100 beneficial actions that naturally provide you with a well-coordinated, responsive immunity boost within 20 minutes.

If you need a strong boost in the energetics and recovery, take Signalom™ Pro-Sport.  If you’re not risking overly intensive activity, you might prefer a bit more of the antioxidant action, take Signalom™ Active. Often, people mix the two taking Signalom™ Pro-Sport on heavy work or intensive exercise days, and taking Signalom™ Active on all other days.

What is a biohack?

A biohack refers to actions that people take to make their bodies and brains function better. Signalom™ formulations are natural “biohacks” because you can induce all of these beneficial actions on your own with the proper technique and exercise regime (you can learn much more by looking up “hypoxia preconditioning” in your search engine)!  The issue is that it takes quite a bit of energy and understanding to trigger these adaptive responses on your own and how do you know if you’re doing enough, or too much, right?

We can help.

For those who wish to learn more, provided here is the link to an excellent and relevant academic manuscript entitled, “Effect of exercise on the immune system: response, adaptation and cell signaling.”

https://www.scielo.br/pdf/rbme/v18n3/en_15.pdf

Summary: Over the last century, people have become less active, adopting more sedentary habits. This scenario has increased the incidence of chronic diseases such as cardiovascular diseases, type 2 diabetes and metabolic syndrome. The practice of physical activities can influence healthiness by altering the metabolic state and also the immune system. The current state of knowledge suggests that the alterations in the immune system are dependent on parameters inherent to exercise and that in order to have all these alterations occurring, some cell signaling cascades are activated, giving rise to a complex process of phosphorylation/dephosphorylation that culminates in the activation of transcription factors, translation of mRNA’s, protein synthesis and cell proliferation.

 Generally speaking, exercise of moderate intensity promotes protection against infections caused by intracellular microorganisms, since it guides the immune response to a predominance of Th1 cells. Conversely, high-intensity activities cause increases the concentrations of anti-inflammatory cytokines (Th2 pattern), presumably to decrease damage in muscular tissue resulting from inflammation.

The Signalom™ biohack is that exact, beneficial activation, and the secret is a Goldilocks signal—too short or weak a signal to the hypothalamus in your brain and nothing happens, too long-term or strong a signal and you can suppress some important benefits.  You only need enough to make a proper signal, not to perform a function.  Use the science to your advantage!  When the signal strength is adequate then you get all of the short and long-term benefits of a well-coordinated and responsive immunity boost.  Exercise and enjoy life to its fullest—its great for your health and immunity!

What makes up the immune system?

♦  In general, there are two parts to the human immune system: innate (or broad-spectrum) and adaptive.

♦  Innate immune cells are found both in circulating blood and in tissues and are the first to engage pathogens, normally within several hours or up to several days after infection when the pathogen load is low

♦  Innate immune cells lack the ability to specifically identify pathogens, they just know that it is not one of ours and must be destroyed; dead pathogens are ultimately transported to the thymus gland where innate and adaptive immunity meet.

♦  After obtaining the specific pathogen information from innate immune cells in the thymus gland, adaptive immune cells are subjected to rigorous training in order to quickly learn how to recognize and kill the pathogen and not confuse it with our own cells; upon successful training, new adaptive immune cells are mass produced, called ‘clonal expansion,’ normally taking around 4-7 days after infection.

Why is oxygen important in immunity?

♦  Immune cells use inflammation to kill pathogens

♦  Inflammation requires energy and most cellular energy is made using oxygen

♦  Many types of immune challenges can quickly deplete cellular oxygen

♦  In almost all cases, the first and most important order of business is to restore cellular oxygen and energy

Activate Biophysics Corp. is a privately held technology company incorporated in Vancouver, British Columbia. Since 2015, the Company’s founders commissioned testing and human trials for a unique, non-toxic and highly effective line of dietary supplements. The Company was formed to bring these products to market in North America, the EU and Asia. The Company has applied for patent protection for all of its unique formulations.

The mission of the Company is to develop, manufacture and market non-toxic, highly effective dietary supplements throughout the world. Our vision is to become the world’s primary supplier of biophysics-based dietary supplements.

In accordance with our mission statement, the Company is currently developing a pipeline of additional non-toxic and highly effective products and supplements to help provide our customers (and ourselves) with optimum health.